Caplyta meets main goal in bipolar mania study

Johnson and Johnson reported that its experimental use of Caplyta successfully met the primary goal in a late stage study for treating bipolar mania. The drug significantly reduced symptoms compared to a placebo, offering potential new treatment benefits.

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People gather next to a logo of Johnson & Johnson at the company’s booth at the 8th China International Import Expo (CIIE) in Shanghai, China, November 6, 2025.REUTERS/Maxim Shemetov

JOHNSON & JOHNSON said on Monday morning its experimental use of Caplyta for bipolar mania met the main goal of a late-stage study. The trial advances the drug toward expanding beyond its currently approved indications. Caplyta is central to the company's neuroscience portfolio following its $14.6B acquisition of Intra-Cellular Therapies.

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