US drug overdose deaths fell nearly 14 percent in 2025

US drug overdose deaths fell nearly 14 percent in 2025 to 69,973. CDC data shows a third year of declines as naloxone availability helped reduce fatalities.

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The United States recorded a 14% drop in drug overdose deaths to 69,973 in 2025. This marks the third consecutive annual decline according to provisional data from the Centers for Disease Control and Prevention. The CDC's estimates underscore the impact of public health interventions like naloxone distribution in reversing the opioid crisis.

Naloxone Access Drives Opioid Death Decline

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